Owen Hargreaves and Gary Neville have been left out of Manchester United's squad for their crucial Champions League clash against Aalborg on Tuesday.
England midfielder Hargreaves is struggling with a knee injury that has bothered him since his arrival from Bayern Munich last season and has been left at home for more treatment.
United captain Neville seemed to come through Saturday's win over Bolton unscathed after almost 18 months on the sidelines following major ankle surgery and several other injuries.
His absence from the trip to Denmark is yet to be explained by United and Wes Brown is likely to deputise at right-back.
Ferguson's side need a win on Tuesday after drawing their opening match against Villarreal and Dimitar Berbatov, Carlos Tevez, Cristiano Ronaldo and Wayne Rooney are vying for the striking positions.